| Nuclear genes with apicoplast signal sequences |
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|
|
| Compiled with assistance from Stuart Ralph |
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|
|
| Function |
PfID |
Formal annotation with curator's notes |
|
Transcript |
EC # |
| Replication
and transcription |
|
|
|
PFB0180w |
5'-3' exonuclease, N-terminal resolvase-like domain, putative |
|
|
2.7.7.7 |
|
PF11_0074 |
exonuclease, putative |
|
|
3.1.13.2 |
|
PF11_0306 |
A/G-specific adenine glycosylase, putative |
|
|
3.2.2.- |
|
PFC0250c |
AP endonuclease (DNA-(apurinic or apyrimidinic site) lyase),
putative |
|
|
4.2.99.18 |
|
PFE0205w |
ATP-dependent helicase, putative |
|
|
3.6.1.3 |
|
PFE0215w |
ATP-dependent helicase, putative |
|
|
3.6.1.3 |
|
PF13_0077 |
DEAD box helicase, putative |
|
|
3.6.1.3 |
|
PFL1120c |
DNA GyrAse a-subunit, putative |
|
|
5.99.1.3 |
|
PFL1915w |
DNA gyrase subunit b, putative |
|
|
5.99.1.3 |
|
MAL13P1.22 |
DNA ligase 1 |
|
|
6.5.1.1 |
|
PF13_0040 |
DNA-directed RNA polymerase alpha chain, putative |
|
|
2.7.7.6 |
|
PF14_0695 |
DNA-directed RNA polymerase, alpha subunit, truncated,
putative |
|
|
2.7.7.6 |
|
PF10_0369 |
helicase, putative |
|
|
3.6.1.3 |
|
MAL7P1.151 |
modification methylase-like protein |
|
|
2.1.1.37 |
|
PFI0525w |
nucleotide binding protein, putative |
|
|
3.6.1.3 |
|
PFB0890c |
pseudouridine synthetase, putative |
|
|
4.2.1.70 |
|
PFI0685w |
pseudouridylate synthase, putative |
|
|
4.2.1.70 |
|
PFL1380w |
RNA pseudouridylate synthase, putative |
|
|
4.2.1.70 |
|
PFI0920c |
dihydrouridine synthase, putative |
|
|
|
|
|
single-strand binding protein, putative |
|
|
|
|
PFL2395c |
dimethyladenosine transferase, putative |
|
|
2.1.1.- |
|
PFA0580c |
TatD-like deoxyribonuclease, putative |
|
|
3.1.21.- |
|
PFE0420c |
guanidine nucleotide exchange factor, putative |
|
|
|
|
PFI0700c |
Met-10+ like protein, putative |
|
|
|
|
PFL2030w |
queuine tRNA ribosyltransferase, putative |
|
|
2.4.2.29 |
|
PF13_0109 |
N2,N2-dimethylguanosine tRNA methyltransferase, putative |
|
|
2.1.1.32 |
|
PFB0855c |
hypothetical protein; SpoU, rRNA methylase |
|
|
2.1.1.66 |
|
PF11_0212 |
tRNA
nucleotidyltransferase, putative |
|
|
2.7.7.25 |
|
PF13_0176 |
apurinic/apyrimidinic endonuclease Apn1 |
|
|
4.2.99.18 |
|
|
Plastid replication-repair enzyme, PREX, POM1 |
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|
|
|
|
bacterial histone-like protein |
|
|
|
| Translation |
|
|
|
|
PF11_0065 |
ribosomal protein S4, putative |
|
|
|
|
PFI1585c |
30S ribosomal protein S6-like protein, putative |
|
|
|
PF14_0132 |
ribosomal protein S9, putative |
|
|
|
|
PF14_0581 |
ribosomal protein S10, putative |
|
|
|
PF11_0386 |
30S ribosomal protein S14, putative |
|
|
|
|
PF11_0072 |
apicoplast
ribosomal protein S15 precursor, putative |
|
|
|
PF14_0205 |
ribosomal protein S25, putative |
|
|
|
|
PFL0500w |
50S ribosomal protein L1, putative |
|
|
|
|
PF11_0337 |
50S ribosomal protein L2, putative |
|
|
|
|
PFB0545c |
ribosomal protein L7/L12, putative |
|
|
|
|
PFD0675w |
ribosomal protein L10, putative |
|
|
|
|
PFE1225w |
50S ribosomal subunit protein L12, putative |
|
|
|
|
PF14_0296 |
ribosomal protein L14, putative |
|
|
|
|
PF14_0270 |
ribosomal protein L15, putative |
|
|
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PFF0650w |
ribosomal protein L18, putative |
|
|
|
|
PF08_0014 |
plastid 50S ribosomal protein, putative;
L21 |
|
|
|
|
PF14_0642 |
organelle
ribosomal protein L22/L17 precursor, putative |
|
|
|
|
PF10_0332 |
ribosomal protein L27, putative |
|
|
|
|
PFE0145w |
50S ribosomal subunit protein L28, putative |
|
|
|
|
PFL0400w |
50S ribosomal protein L29, putative |
|
|
|
|
PFI0375w |
ribosomal protein L35 with long N-terminal extension, putative |
|
|
|
|
PF14_0658 |
translation initiation factor EF-1, putative |
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|
|
|
|
elongation factor (EF-TS), putative |
|
|
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|
PFF0115c |
elongation factor G, putative |
|
|
|
|
MAL7P1.20 |
peptide chain release factor |
|
|
|
|
PF14_0265 |
peptide chain release factor 1, putative |
|
|
|
MAL7P1.20 |
peptide chain release factor |
|
|
|
|
PF14_0265 |
peptide chain release factor 1, putative |
|
|
|
|
PFB0390w |
ribosome releasing factor, putative |
|
|
|
|
|
peptide deformylase |
|
|
3.5.1.88 |
|
PF13_0354 |
alanine-tRNA ligase, putative |
|
|
6.1.1.7 |
|
PFL0900c |
arginyl-tRNA synthetase, putative |
|
|
6.1.1.19 |
|
PFI0680c |
arginyl-tRNA synthetase, putative |
|
|
6.1.1.19 |
|
PFE0475w |
asparaginyl-tRNA ligase, putative |
|
|
6.1.1.22 |
|
PFE0715w |
asparaginyl-tRNA ligase, putative |
|
|
6.1.1.22 |
|
PF10_0149 |
cysteinyl-tRNA ligase, putative |
|
|
6.1.1.16 |
|
MAL13P1.281 |
glutamyl-tRNA ligase, putative |
|
|
6.1.1.17 |
|
PFD0780w |
glutamyl-tRNA(Gln) amidotransferase subunit A, putative |
|
|
6.3.5.7 |
|
PF14_0198 |
glycyl-tRNA ligase, putative |
|
|
6.1.1.14 |
|
PFL1210w |
isoleucyl-tRNA synthetase, putative |
|
|
6.1.1.5 |
|
PFI1645c |
histidyl-tRNA synthetase, putative |
|
|
6.1.1.21 |
|
PF08_0011 |
leucyl-tRNA ligase |
|
|
6.1.1.4 |
|
PF14_0166 |
lysyl-tRNA ligase, putative |
|
|
6.1.1.6 |
|
MAL13P1.67 |
methionyl-tRNA formyltransferase, putative |
|
|
2.1.2.9 |
|
PFL1540c |
phenylalanyl-tRNA synthetase alpha chain, putative |
|
|
6.1.1.20 |
|
PFI1240c |
prolyl-t-RNA synthase, putative |
|
|
6.1.1.15 |
|
PF07_0073 |
seryl-tRNA synthetase, putative |
|
|
6.1.1.11 |
|
PFL0770w |
seryl-tRNA synthetase, putative |
|
|
6.1.1.11 |
|
PF11_0270 |
threonine-tRNA ligase, putative |
|
|
6.1.1.3 |
|
PFL0380c |
tRNA delta(2)-isopentenylpyrophosphate transferase, putative |
|
|
2.5.1.8 |
|
PF10_0053 |
methionyl-tRNA synthetase |
|
|
6.1.1.10 |
|
PF10_0175 |
tRNA pseudouridine synthase, putative |
|
|
4.2.1.70 |
|
PF13_0205 |
tryptophanyl-tRNA ligase, putative |
|
|
6.1.1.2 |
|
PFL2485c |
tryptophanyl-tRNA synthetase, putative |
|
|
6.1.1.2 |
|
PF11_0181 |
tyrosinyl-tRNA ligase, putative |
|
|
6.1.1.1 |
|
PFC0470w |
valiyl-tRNA ligase, putative |
|
|
6.1.1.9 |
|
MAL8P1.27 |
translation
initiation factor IF-3, putative |
|
|
|
PFD0355c |
peptidyl-tRNA
hydrolase PTH2, putative |
|
|
|
|
PF10_0200 |
ribosomal processing ATPase, putative |
|
|
|
| Isoprenoid
biosynthesis |
|
|
|
|
PF14_0641 |
1-deoxy-D-xylulose 5-phosphate reductoisomerase |
|
|
1.1.1.267 |
|
MAL13P1.186 |
1-deoxy-D-xylulose 5-phosphate synthase |
|
|
2.2.1.7 |
|
PFB0420w |
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
|
|
4.6.1.12 |
|
|
4-diphosphocytidyl-2c-methyl-D-erythritol kinase (CMK),
putative |
|
|
2.7.1.148 |
|
PF10_0221 |
GcpE protein, 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
synthase |
|
|
1.17.4.3 |
|
PFA0225w |
LytB protein, 4-hydroxy-3-methylbut-2-enyl diphosphate
reductase |
|
|
1.17.1.2 |
| Fatty
acid and phospholipid metabolism |
|
|
|
|
PFI1125c |
3-oxoacyl-(acyl-carrier protein) reductase, putative |
|
|
1.1.1.100 |
|
MAL6P1.165 |
3-oxoacyl-(acyl-carrier-protein) synthase i/ii |
|
|
2.3.1.41 |
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|
acyl carrier protein, putative |
|
|
|
|
PFB0685c |
long-chain-fatty-acid-CoA ligase; PfACS9 |
|
|
6.2.1.3 |
|
PFB0695c |
long-chain-fatty-acid-CoA ligase |
|
|
6.2.1.3 |
|
PFL0035c |
acyl-CoA synthetase,
PfACS7 |
|
|
6.2.1.3 |
|
PF13_0128 |
beta-hydroxyacyl-acp dehydratase precursor |
|
|
4.2.1.- |
|
PFB0505c |
beta-ketoacyl-acyl carrier protein synthase III precursor,
putative |
|
|
2.3.1.41 |
|
PF14_0664 |
biotin carboxylase subunit of acetyl CoA carboxylase, putative |
|
|
6.4.1.2 |
|
PF14_0415 |
dephospho-CoA kinase, putative |
|
|
2.7.1.24 |
|
PFI1485c |
diacylglycerol kinase, putative |
|
|
2.7.1.107 |
|
PF10_0407 |
dihydrolipoamide acetyltransferase, putative |
|
|
2.3.1.12 |
|
PFF0730c |
enoyl-acyl carrier reductase |
|
|
1.3.1.9 |
|
PF13_0100 |
glycerol-3-phosphate acyltransferase, putative |
|
|
2.3.1.15 |
|
PFD0980w |
holo-(acyl-carrier protein) synthase, putative |
|
|
2.7.8.7 |
|
MAL13P1.335 |
phosphatidylserine synthase i; putative |
|
|
2.7.8.8 |
|
|
lipoamide dehydrogenase, putative |
|
|
1.8.1.4 |
|
MAL13P1.220 |
lipoate synthase, putative |
|
|
2.8.1.8 |
|
MAL8P1.37 |
lipoate-protein ligase, putative |
|
|
2.3.1.- |
|
PF13_0066 |
malonyl coa-acyl carrier protein transacylase precursor |
|
|
2.3.1.39 |
|
PF07_0129 |
Acyl-CoA synthetase, PfACS5 |
|
|
6.2.1.- |
|
PFD1035w |
steroid dehydrogenase kik-i, putative |
|
|
1.1.1.- |
|
MAL13P1.285 |
hypothetical protein; Patatin-like phospholipase; Ca2+-independent phospholipase A2 |
|
|
3.1.1.4 |
|
PFI1180w |
hypothetical protein; Patatin family phospholipase, putative |
|
|
3.1.1.4 |
|
PFI0695c |
phospholipid or glycerol acyltransferase, putative |
|
2.3.1.- |
|
MAL8P1.202 |
apicoplast phosphatidic acid phosphatase, putative |
|
|
3.1.3.4 |
|
PFE0555w |
stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid
desaturase), putative |
|
|
1.14.19.1 |
|
PF14_0441 |
pyruvate dehydrogenase E1 beta subunit, putative |
|
|
1.2.4.1 |
|
PF11_0256 |
pyruvate dehydrogenase E1 component, alpha subunit, putative |
|
|
1.2.4.1 |
|
|
pyruvate kinase, putative |
|
|
2.7.1.40 |
|
PFC0831w |
triosephosphate isomerase, putative |
|
|
5.3.1.1 |
|
PFC0260w |
hypothetical protein, conserved; Possibly
adenylate kinase |
|
|
2.7.4.3 |
| Transport |
|
|
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|
PFC0125w |
ABC transporter, putative |
|
|
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PF13_0271 |
ABC transporter, putative |
|
|
|
|
PF08_0078 |
hypothetical protein; ABC transporter, putative |
|
|
|
|
|
cation-transporting ATPase 1 |
|
|
3.6.3.12 |
|
PFE0195w |
P-type ATPase,
putative; PfATPase3 |
|
|
3.6.3.12 |
|
PF07_0115 |
cation transporting ATPase, putative |
|
|
3.6.3.12 |
|
|
Phosphoenolpyruvate / phosphate translocator precursor,
putative |
|
|
|
|
PF11_0466 |
transport protein, putative |
|
|
|
|
|
triose or hexose phosphate / phosphate translocator, putative |
|
|
|
|
PF14_0369 |
hypothetical protein; Ctr copper
transporter family |
|
|
|
| Antoxidant
defense |
|
|
|
|
|
antioxidant protein, putative |
|
|
|
|
|
glutathione peroxidase |
|
|
1.11.1.9 |
|
PF11_0055 |
Hypothetical protein; protein disulfide isomerase like thioredoxin domain containing
protein |
|
|
|
|
|
glyoxalase I, putative |
|
|
4.4.1.5 |
|
PF14_0508 |
pyridine nucleotide transhydrogenase, putative |
|
|
1.6.1.1 |
|
MAL13P1.324 |
aldo-keto reductase, putative |
|
|
1.-.-.- |
|
|
Fe-superoxide dismutase |
|
|
1.15.1.1 |
| Protein
folding |
|
|
|
|
PF07_0103 |
chaperone, putative; DnaJ domain |
|
|
|
|
PF11_0443 |
hypothetical protein, conserved; DnaJ
domain containing protein |
|
|
|
|
|
chaperonin cpn60 |
|
|
|
|
|
chaperonin, putative |
|
|
|
|
PF11_0175 |
heat shock protein 101, putative |
|
|
|
|
PF11_0099 |
heat shock protein DnaJ homologue Pfj2 |
|
|
|
|
PFB0920w |
hypothetical protein; DnaJ-class molecular chaperone with C-terminal Zn finger domain |
|
|
|
|
PF14_0417 |
heat shock protein, putative |
|
|
|
|
PFL2015w |
hypothetical protein; Tetratricopeptide
repeat protein 1 |
|
|
| Fe-S
cluster production |
|
|
|
|
PF07_0068 |
cysteine desulfurase, putative; SufS-like |
|
|
2.8.1.7 |
|
|
cysteine desulfurase, putative; NifS-like |
|
|
2.8.1.7 |
|
PFI1050c |
hypothetical protein; NifU-like domain.
iron-sulfur cluster assembly protein |
|
|
|
|
PF11_0044 |
hypothetical protein; Cysteine desulfurase
activator SufB/SulfD |
|
|
2.8.1.7 |
|
PF14_0133 |
Fe-S assembly ATPase SufC |
|
|
|
|
PFB0270w |
hypothetical protein, conserved; SufE -
involved in Fe-S protein metabolism |
|
|
|
|
MAL13P1.95 |
ferredoxin |
|
|
|
|
PFF1115w |
ferredoxin-NADP reductase, putative |
|
|
1.18.1.2 |
| Porphyrin
biosynthesis |
|
|
|
|
|
delta-aminolevulinic acid dehydratase |
|
|
4.2.1.24 |
|
|
porphobilinogen deaminase, putative |
|
|
2.5.1.61 |
|
|
uroporphyrinogen decarboxylase |
|
|
4.1.1.37 |
|
PF14_0155 |
hypothetical protein; glycine
C-acetyltransferase |
|
|
2.3.1.29 |
| Post-translational
modification and Proteolysis |
|
|
|
MAL13P1.255 |
N6-adenine-specific
methylase, putative |
|
|
|
|
aspartyl (acid) protease, putative; plasmepsin V |
|
|
3.4.23.- |
|
PF14_0348 |
ATP-dependent Clp protease proteolytic subunit, putative |
|
|
3.4.21.92 |
|
|
ATP-dependent Clp protease, putative |
|
|
3.4.21.92 |
|
PF14_0063 |
ATP-dependent Clp protease, putative |
|
|
3.4.21.92 |
|
MAL13P1.111 |
ATP-dependent
Clp protease adaptor protein ClpS containing protein |
|
|
|
|
PF08_0063 |
ClpB protein, putative |
|
|
|
|
PFL1780w |
Protein-S-isoprenylcysteine
O-methyltransferase, putative |
|
|
2.1.1.100 |
|
|
leucine aminopeptidase, putative |
|
|
3.4.11.1 |
|
|
m1-family
aminopeptidase; membrane alanyl aminopeptidase |
|
|
3.4.11.2 |
|
PF14_0382 |
metalloendopeptidase, putative |
|
|
3.4.24.55 |
|
MAL8P1.140 |
methionyl aminopeptidase, putative |
|
|
3.4.11.18 |
|
|
peptidase,
putative; Xaa-Pro aminopeptidase |
|
|
3.4.14.5 |
|
PFD0230c |
dipeptidyl peptidase 3 |
|
|
3.4.14.4 |
|
PFI0660c |
protease, putative |
|
|
|
|
PF11_0174 |
dipeptidyl
peptidase 1 cathepsin C, homolog |
|
|
3.4.14.1 |
|
PF10_0308 |
OTU-like
cysteine protease, putative |
|
|
|
|
PF11_0464 |
Serine/Threonine protein kinase, catalytic domain |
|
|
2.7.11.1 |
|
PF14_0660 |
Protein phosphatase |
|
|
3.1.3.16 |
|
PF14_0524 |
Protein phosphatase |
|
|
3.1.3.16 |
| Unknown
function in apicoplast (16.5 % of all genes; 32.4 % of annotated genes) |
|
|
|
|
cysteine repeat modular protein 2 homologue |
|
|
|
|
PF10_0245 |
glucosamine-fructose-6-phosphate aminotransferase, putative |
|
|
2.6.1.16 |
|
PF14_0286 |
glutamate dehydrogenase, putative |
|
|
1.4.1.4 |
|
PFL0835w |
GTP-binding protein, putative; ATP-deptendent acyl-CoA
synthetase, putative ? |
|
|
|
|
PF14_0114 |
GTP-binding protein, putative |
|
|
|
|
PFC0330w |
PDZ domain protein, putative |
|
|
|
|
MAL13P1.196 |
Serine/threonine protein kinase, putative |
|
|
2.7.11.1 |
|
PF13_0344 |
UBA/THIF-type NAD/FAD binding protein, putative |
|
|
|
|
PFA0555c |
UMP-CMP kinase, putative |
|
|
2.7.4.14 |
|
MAL13P1.221 |
aspartate carbamoyltransferase |
|
|
2.1.3.2 |
|
MAL13P1.227 |
ubiquitin-conjugating enzyme, putative |
|
|
|
|
PF08_0067 |
hypothetical protein; Ubiquitin family
protein |
|
|
|
|
PF13_0182 |
hypothetical protein; Ub E1 domain |
|
|
|
|
MAL13P1.171 |
transmembrane protein Tmp21 homologue, putative |
|
|
|
|
PF07_0047 |
cell
division cycle ATPase, putative; cell division cycle protein 48 homologue,
putative |
|
|
|
|
PF08_0138 |
RIFIN |
|
|
|
|
PF10_0003 |
RIFIN |
|
|
|
|
PF10_0006 |
RIFIN |
|
|
|
|
PF10_0394 |
RIFIN |
|
|
|
|
PF14_0770 |
RIFIN |
|
|
|
PFD0070c |
RIFIN |
|
|
|
|
PF11_0010 |
RIFIN |
|
|
|
|
PFC0040w |
RIFIN |
|
|
|
|
PFB0035c |
RIFIN |
|
|
|
PFB0055c |
RIFIN |
|
|
|
|
PFD0640c |
RIFIN |
|
|
|
|
PFE1630w |
RIFIN |
|
|
|
|
PFF0855c |
RIFIN |
|
|
|
PFF1545w |
RIFIN |
|
|
|
|
PFF1560c |
RIFIN |
|
|
|
PFC0045w |
RIFIN-like protein |
|
|
|
|
PF11_0022 |
RIFIN pseudogene |
|
|
|
PFF1585w |
RIFIN pseudogene |
|
|
|
MAL13P1.7 |
STEVOR |
|
|
|
PF07_0130 |
STEVOR |
|
|
|
PFA0750w |
STEVOR |
|
|
|
|
PFD1220c |
STEVOR |
|
|
|
|
PFD0125c |
STEVOR |
|
|
|
PFL2610w |
STEVOR |
|
|
|
PFF0850c |
STEVOR |
|
|
