Nuclear genes with mitochondrial signal sequences
Compiled by A.B. Vaidya and M.W. Mather. Additional annotations by the curator are in green letters.
Function PfID Annotation Transcript EC #
Replication
PFF1225c DNA polymerase 1, putative
2.7.7.7
MAL13P1.166 Helicase; DNA polymerase Theta subunit
2.7.7.7
PFB0215c 3'-5' exonuclease
3.1.1.-
PFI0835c N-glycosylase/DNA lyase
PFC0250c AP endonuclease (DNA-(apurinic or apyrimidinic site) lyase), putative
4.2.99.18
PFF0715c Endonuclease iii homologue, putative
4.2.99.18
Transcription
PF13_0177 ATP-dependent RNA helicase
3.6.3.-
PFD0245c ATP-dependant RNA helicase-like protein
3.6.3.-
PFL1310c ATP-dependent RNA helicase, putative
3.6.3.-
MAL7P1.113 DEAD box helicase
3.6.3.-
PF14_0429 RNA helicase
3.6.3.-
MAL8P1.19 RNA helicase, putative
3.6.3.-
PF10_0369 Helicase; TFIIH basal transcription factor complex helicase XPB subunit 
3.6.3.-
PF14_0695 DNA-directed RNA polymerase, alpha subunit, truncated
2.7.7.6
PF13_0150 DNA-directed RNA polymerase 3 largest subunit
2.7.7.6
PF11_0264 DNA-directed RNA polymerase
2.7.7.6
MAL6P1.68 Polypyrimidine tract binding protein
PF07_0071 Queuine tRNA-ribosyltransferase
2.4.2.29
PFL2030w Queuine tRNA ribosyltransferase
2.4.2.29
PFE1080w Ribosomal large subunit pseudouridylate synthase, putative
5.4.99.12
PFE1275c RNA methyltransferase, putative
2.1.1.-
PF11_0284 Methyltransferase; tRNA (guanine-N7-)-methyltransferase 
2.1.1.33
PFL2395c Dimethyladenosine transferase, putative
2.1.1.62   
PF14_0156 Dimethyladenosine transferase, putative
2.1.1.62   
PFF0745c Ribonuclease
3.1.-.-
PFA0580c TatD-like deoxyribonuclease, putative
PF13_0349 Nucleoside diphosphate kinase b
2.7.4.6
Translation
Rounded Rectangle: Translation in prokaryotes – a template for apicoplast and mitochondrion

Import of proteins into the mitochondrion
PF13_0262 Lysyl-tRNA ligase
6.1.1.6
PF14_0166 Lysyl-tRNA synthetase protein, putative
6.1.1.6
PFF0180w Phenylalanyl-tRNA synthetase, putative
6.1.1.20
PF11_0270 Threonyl-tRNA synthetase, putative
6.1.1.3
PF14_0589  Valyl-RNA synthetase
6.1.1.9
PFL1590c Elongation factor g
MAL13P1.164 Elongation factor tu, putative
PF13_0069 Translation initiation factor if-2
MAL7P1.20 Peptide chain release factor, putative
PFI1575c Peptide release factor, putative
PF14_0584 Mitochondrial ribosomal protein S4/S9 precursor, putative
MAL7P1.66 Mitochondrial ribosomal protein S5 precursor, putative
PFI1585c Mitochondrial ribosomal protein S6 precursor, putative
PF14_0606 Mitochondrial ribosomal protein S6-2 precursor, putative
MAL7P1.93 Mitochondrial ribosomal protein S8, putative 
PF11_0382 Ribosomal protein S9, putative 
PF14_0519 Ribosomal protein S11, putative 
PFD0600c Mitochondrial ribosomal protein S12 precursor, putative
PF14_0451 Mitochondrial ribosomal protein S14 precursor, putative
PF13_0059 Ribosomal protein S15, Mitochondrial precursor, putative 
PFE1560c Mitochondrial ribosomal protein S16 precursor, putative
MAL13P1.327 Ribosomal protein S17 homologue, putative 
PFL0570c Mitochondrial ribosomal protein S18 precursor, putative
PF10_0267 Mitochondrial ribosomal protein S22 precursor, putative
PF14_0430 Mitochondrial ribosomal protein S29 precursor, putative
PF13_0068 Mitochondrial ribosomal protein S35 precursor, putative
PFC0675c Mitochondrial ribosomal protein S39 precursor, putative
PF07_0046  50S ribosomal protein L1, putative
PFL0500w 50S ribosomal protein L1, putative 
PF11_0337 50S ribosomal protein L2, Mitochondrial, putative 
PFL2180w  50S ribosomal protein L3, putative
PFI0890c Large ribosomal subunit protein L3, prokaryotic (50S)-like, putative 
PF08_0038 50S ribosomal protein L4, putative
MAL13P1.318 Ribosomal protein L9, putative
PF11_0113 Ribosomal protein L11, putative (50S)
PFB0545c Ribosomal protein L7/L12, putative (50S)
PFE1225w 50S ribosomal subunit protein L12, putative
PFE0960w 50S ribosomal subunit protein L14, putative
PFE1125w 50S ribosomal subunit protein L17, putative
PF14_0276 Ribosomal protein L15, putative (50S) 
PF14_0041 Ribosomal protein L16, putative 
PF14_0289 Ribosomal protein L17, putative 
PFF0495w Ribosomal protein L19-like protein, putative
PF14_0709 Ribosomal protein L20, putative 
PF14_0212 Mitochondrial ribosomal protein L21 precursor, putative; (50S)
PF10_0097 Mitochondrial ribosomal protein L22/L43, putative
PFL1895w Ribosomal protein L23, putative 
PFF0245w 50S ribosomal subunit L24, putative 
PFL1150c Ribosomal protein L24, putative 
PFC0701w Mitochondrial ribosomal protein L27 precursor, putative
PF14_0539 Mitochondrial ribosomal protein L28 precursor, putative  
PFE0145w  50S ribosomal subunit protein L28, putative
PFL0400w 50S ribosomal protein L29, putative 
PFF1305w Mitochondrial ribosomal protein L46 precursor, putative  
MAL13P1.200 Mitochondrial ribosomal protein L49 precursor, putative  
PFE1470w RNA-binding protein, putative 
PFL1710C tetQ family GTPase, putative
PFE1090w Nuceotide binding protein, putative; ATPase
Peptide import and processing
MAL13P1.184 Endopeptidase, putative; mitochondrial intermediate processing peptidase
3.4.24.59
PF10_0080 Endonuclease, putative; similar to FLAP endonuclease
4.2.99.18
PFE1155c Mitochondrial processing peptidase alpha subunit, putative
3.4.24.64
PFI1625c Organelle processing peptidase, beta subunit putative
3.4.24.64
PFI0660c Protease, putative
PFI0985c Chaperone protein; DnaJ domain
MAL13P1.162 DNAJ-like protein, putative
PFD0465w Heat shock protein 40 
PF07_0103 Chaperone, putative; DnaJ domain
PF10_0153
Heat shock protein 60; hsp60/cpn60; mitochondrial chaperonin 
PF11_0351 Heat shock protein 70 homologue; DnaK molecular chaperone
PFA0470c Cold-shock protein, putative
.
PF14_0197 Zinc finger protein, putative; possible DNL zinc finger protein similar to Hep1 required for stabilization of mtHSP70 chaparones
PF11_0188 Heat shock protein 90
PF11_0258 Co-chaperone GrpE, putative
PFL0740c
10 kd chaperonin, putative
MAL13P1.139 Tetratricopeptide repeat family protein, putative 
PFL0735w Cyclophilin (peptidyl-prolyl cis-trans isomerase)
5.2.1.8
MAL7P1.69
Calmodulin, putative
PF14_0516 Serine/threonine-protein kinase
2.7.11.1
PFE1230c Mitochondrial import receptor subunit, putative TOM22
PFF0825c Mitochondrial import receptor subunit TOM40
PF14_0328 Mitochondrial import inner membrane translocase subunit TIM17, putative
PFL2065c Mitochondrial import inner membrane translocase, putative; TIM9
PFL2065c Mitochondrial import inner membrane translocase subunit, putative; TIM10
PFL0430w TIM10 mitochondrial import inner membrane translocase homologue, putative
PF14_0208 Mitochondrial protein import protein TIM13, putative 
PFF1330c Mitochondrial import inner membrane translocase subunit, putative; TIM22
PF11_0265 Mitochondrial import inner membrane translocase, putative; TIM44
PF07_0110 Protein phosphatase, putative TIM50 homologue 
PF08_0006 Prohibitin, putative (PHB1)
PF11_0203 Peptidase, putative ; AFG3-like AAA protease, putative 
3.4.11.18
PFL1925w Cell division protein FtsH, putative; Tg AFG3 ATPase family protein
PF13_0118 Peptidase, putative ; mitochondrial inner membrane protease subunit 1 or 2
3.4.21.89
MAL13P1.56
m1-family aminopeptidase
3.4.11.2
PFB0325c Cysteine protease, putative 3.4.22.-
PF14_0517
Peptidase (Xaa-Pro), putative
3.4.11.18
PFB0520w Protein kinase
2.7.11.1
MAL13P1.84 Protein kinase
2.7.11.1
PF10_0160 Serine/Threonine protein kinase, FIKK family
2.7.10.-
PFF0520w Calcium-dependent protein kinase
2.7.11.-
TCA cycle enzymes
Rounded Rectangle: Mitochondrial TCA cycle
PF10_0218
Citrate synthase, mitochondrial precursor, putative
2.3.3.1
PFF0455w Citrate synthase-like protein, putative
2.3.3.1
PF13_0242 Isocitrate dehydrogenase (NADP), mitochondrial precursor
1.1.1.42
PF08_0045 2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor
1.2.4.2
PFE0225w 3-methyl-2-oxobutanoate dehydrogenase (lipoamide), putative
1.2.4.4
PF13_0070 Branched-chain alpha keto-acid dehydrogenase E1 - alpha subunit
1.2.4.4
PF14_0295 ATP-specific succinyl-CoA synthetase beta subunit, putative
6.2.1.5
PF11_0097 Succinyl-CoA synthetase alpha subunit
6.2.1.4 
PFL0630w Succinate dehydrogenase Fe-S subunit
1.3.99.1
PF13_0121 Dihydrolipoamide succinyltransferase, putative
2.3.1.61
PF10_0334 Flavoprotein subunit of succinate dehydrogenase
6.2.1.4 
PFI1340w Fumarate hydratase, putative; fumerate hydratase class I
4.2.1.2
PF13_0229
Irp-like protein; aconitate hydratase 
4.2.1.3
MAL8P1.37 Lipoate-protein ligase; activator of 2-oxoglutarate dehydrogenase
2.7.7.63
PF13_0083 Lipoate-protein ligase a; activator of 2-oxoglutarate dehydrogenase
2.7.7.63
PFL1550w
Dihydrolipoamide dehydrogenase
1.8.1.4 
PFC0170c Dihydrolipoamide acyltransferase, putative [putative E2 of Branched-chain alpha ketoacid dehydrogenase]
2.3.1.12
Biosynthesis of ubiquinone
Rounded Rectangle: Ubiquinone metabolism
PF11_0128  coq4 homolog, putative 
PF14_0147  Lon protease homologue; endopeptidase
3.4.21.53
PF10_0144 Prohibitin/BAP37 (PHB2 homologue)
MAL7P1.130 3-demethylubiquinone-9 3-methyltransferase-like protein, putative
2.1.1.64
PFB0130w polyprenyl synthetase
2.5.1.1
PFF0370w Para-hydroxybenzoate--polyprenyltransferase (4- hydroxybenzoate octaprenyltransferase), putative
2.5.1.39
PFB0220w UbiE-like methlytransferase, putative
2.1.1.-
PF08_0068 FAD-binding monooygenase
1.14.13.8
Components of the respiratory chain
Rounded Rectangle: Mitochondrial electron flow
PFI0735c NADH dehydrogenase, putative; rotenone-insensitive NADH dehydrogenase
1.6.99.3
PFC0275w FAD-dependent glycerol-3-phosphate dehydrogenase, putative
1.1.5.3
PFF0815w Malate:quinone oxidoreductase, putative
1.1.5.4
PF14_0373 Ubiquinol cytochrome c oxidoreductase, putative; rieske Fe-S protein 3
1.10.2.2
PF10_0120 Ubiquinol-cytochrome c reductase complex subunit, putative
1.10.2.2
PF14_0248 Ubiquinol-cytochrome c reductase hinge protein, putative
1.10.2.2
PF14_0038 Cytochrome c, putative
PF14_0597 Cytochrome c1 precursor, putative
PFF0155w BCS1-like protein, putative; required for the assembly of the cytochrome bc(1) complex 
PFI1375w Cytochrome C oxidase, putative 1.9.3.1
PFI1365w Cytochrome c oxidase subunit, putative 1.9.3.1
PF13_0327 Cytochrome c oxidase subunit 2, putative
1.9.3.1
PF14_0288 Cytochrome c oxidase subunit II precursor, putative
1.9.3.1
PF07_0032 Cg8; Cytochrome c oxidase subunit IV
PF14_0721 Cytochrome c oxidase assembly protein
PF14_0331 Cytochrome c oxidase assembly protein, putative
PFE0970w Cytochrome c oxidase assembly protein (heme A: farnesyltransferase), putative
MAL8P1.14 Mitochondrial inner membrane translocase, putative ; similar to Oxa1 proteins involved in cytochrome oxidase assembly
MAL13P1.55 Cytochrome c2 precursor,putative
PFL1725w ATP synthase beta chain, mitochondrial precursor, putative
3.6.3.14
PF13_0061 ATP synthase gamma chain, mitochondrial precursor, putative
3.6.3.14
PFB0795w ATP synthase F1, alpha subunit, putative
3.6.3.14
MAL13P1.47 Mitochondrial ATP synthase delta subunit, putative
3.6.3.14
PF11_0485 Mitochondrial ATP synthase delta subunit, putative  
3.6.3.14
MAL7P1.75 Mitochondrial ATP synthase F1, epsilon subunit, putative 3.6.3.14
MAL7P1.340 ATP synthase subunit c, putative; F0 (ATP9) proteolipid subunit 3.6.3.14
PFF0160c
Dihydroorotate dehydrogenase, mitochondrial precursor
1.3.3.1
Transporters
Rounded Rectangle: Transporters of the mitochondrial and apicoplast membranes
PF08_0098 ABC transporter
PFL0495c ABC transporter; MTABC3 is a mitochondrial ATP-binding cassette protein involved in iron homeostasis 
PF08_0098 ABC transporter, putative; Chaperone, ABC1 activity of bc1 complex
PF11_0466 Transport protein, putative; ABC transporter
PFD0835c LETM1-like protein, putative; protein of the inner mitochondrial membrane which plays a role in potassium and hydrogen ion exchange.
PFL0110c PfmpC; mitochondrial phosphate carrier
PFI0425w Transporter, putative; Solute carrier family 25 phosphate carrier
PFF0170w Calcium antiporter, putative; Ca2+/H+ antiporter
PFL1700c
Vacuolar-type H+-translocating inorganic pyrophosphatase 
PF10_0366
ADP/ATP transporter on adenylate translocase
PF10_0051 ADP/ATP carrier protein, putative, ANT2 
MAL8P1.92 ATPase, putative; similar to Transitional Endoplasmic Reticulum Mg2+-ATPase
PFL2375c cutA, putative; periplasmic cation tolerance protein
PF14_0301 Conserved protein, unknown function; VDAC?
PF08_0031 Oxoglutarate/malate translocator protein, putative
PFI0255c Mitochondrial carrier protein, putative
PFL1145w Mitochondrial carrier protein, putative  
PFL2000w Mitochondrial carrier protein, putative;S-adenosylmethinine transporter 
PF08_0093 Mitochondrial carrier protein, putative; folate transporter
PFA0415c Mitochondrial carrier protein, putative 
PFD0370w / PFD0367w Mitochondrial carrier protein, putative  
PFA0435w Conserved Plasmodium protein, unknown function; mitochondrial carrier family
PF13_0359 Mitochondrial carrier protein, putative
Porphyrin and cytochrome synthesis
Rounded Rectangle: Porphyrin metabolism
PFL2210w
5-aminolevulinate synthase/Delta aminolevulinic acid synthase
2.3.1.37
PFL1185c Cytochrome c heme lyase, putative
4.4.1.17
PFL0180w Cytochrome c1 heme lyase, putative
4.4.1.17
PF07_0034 Cg3; significant similarity to SCO1 copper transport/insertion protein required for cytochrome c oxidase assembly
Fe-S protein biosynthesis
Rounded Rectangle: Mechanism of Fe-S-protein biogenesis
MAL7P1.150
Cysteine desulfurase, putative
2.8.1.7
PFE0795c Nif-like protein; transcriptional regulator 
PFI1835c Nifu-like protein, putative
PF14_0518 NifU protein, putative
PFE1135w Iron-sulfur assembly protein, putative; ISA-like protein
PFB0320c Iron-sulfur assembly protein, putative; ISA-like protein
PFL0705c Adrenodoxin-type ferredoxin, putative
PF07_0085 Ferredoxin reductase-like protein
1.18.1.3
PF11_0407 Mitochondrial NADPH:Ferredoxin oxidoreductase, putative
1.18.1.2
MAL13P1.53 Conserved Plasmodium protein, unknown function; iron-sulfur cluster biosynthesis protein Isd11
PFF1265w NAD-/NADP-dependent oxidoreductase, short-chain dehydrogenase family
1.18.1.-
PF13_0271 ABC transporter, putative; similar to Sc ATM1, involved in iron homeostasis/[Fe-S] export)
PFA0500w Fe/S maturation factor, putative; Erv1
Antioxidant defense
PFL0725w
Thioredoxin peroxidase 
1.11.1.15
MAL13P1.225
Thioredoxin, putative
PFI1250w
Thioredoxin, putative
PFC0205c PfGLP-1, 1-cys-glutaredoxin-like protein-1
PFF1130c
Fe-superoxide dismutase 2, putative 1.15.1.1
PFL0595c
Glutathione peroxidase; 
1.11.1.9
PF14_0192 Glutathione reductase
1.8.1.7
Lipid metabolism
PFF0465c Cardiolipin synthetase, putative
2.7.8.-
PFL0415w Acyl carrier protein, mitochondrial precursor, putative
PF07_0040 Lysophospholipase-like protein, putative
3.1.1.5
MAL6P1.165 3-oxoacyl-(acyl-carrier-protein) synthase I/II
2.3.1.41
One-carbon enzyme systems serine hydroxymethyltransferase and glycine-cleavage complex
PF11_0339 Glycine cleavage system H protein, putative
PF14_0534 Serine hydroxymethyltransferase, putative; SHM
2.1.2.1 
PF13_0345 Aminomethyltransferase, mitochondrial precursor
2.1.2.10
What are they doing there? Genes with mitochondrial signal but with no known function in mitochondria
PF10_0314 Asparagine-rich antigen
PFI0885 Heme-binding protein (cytochrome b5-like)
PF14_0266 Conserved protein, unknown function; Potential heme-binding cytochrome b5-like domain
PFL1555w Cytochrome b5, putative
PFC0730w Conserved protein; TB2/DP1, HVA22 family 
PF13_0353
NADH-cytochrome b5 reductase
1.6.2.2
PFI1140w
NADPH-cytochrome p450 reductase
1.6.2.2
PF14_0114 GTP-binding protein
PFE0665C GTP-binding protein
MAL8P1.33 GTP-binding protein, putative
MAL13P1.301 Guanylyl cyclase
4.6.1.2
PFD0755c Adenylate kinase 1 (GTP-dependent AK)
2.7.4.3
PF10_0086 Adenylate kinase, putative
2.7.4.3 
PFL1920C Hydroxyethylthiazole kinase
2.7.1.50
PF13_0174 P.falciparum homologue of human mbp-1 interacting protein-2a
PFA0330W Asparagine/aspartate rich protein 2
MAL13P1.335 Phosphatidylserine synthase I
2.7.8.8 
PFA0220W Ubiquitin carboxyl-terminal hydrolase
3.4.19.12
PF13_0096 Ubiquitin carboxyl-terminal hydrolase-like zinc finger protein 
3.4.19.12
PF11_0141 UDP-galactose transporter
PFA0075w Var-fragment, pseudogene
PF11_0512 Ring-infected erythrocyte surface antigen 2, RESA
PF10_0380 Trophozoite antigen r45
PF08_0055 U3 small nucleolar ribonucleoprotein
PF11_0524 U6 snRNA associated sm-like protein ls
PFI1710W Cytoadherence-linked protein
PF11_0062 Histone H2 
PFL2165W Kinesin-like protein
PF11_0404 Malaria antigen 
PF14_0493 Sortilin
PFC0800w
Band 7-related protein (SPFH domain / Band 7 family, putative)
PF07_0032 Cg8
PFL0320w Rhodanese like protein, putative; rhodanese-thiosulfate sulfurtransferase 
2.8.1.1
PFI1005w ADP-ribosylation factor-like protein, putative
There are additional 173 hypothetical proteins with mitochondrial signal sequences.