| Genes coding for transport proteins |
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| Source: Martin RE, Henry RI, Abbey JL, Clements JD, Kirk K. The 'permeome' of the malaria parasite: an
overview of the membrane transport proteins of Plasmodium falciparum. Genome
Biol. 2005;6(3):R26. Epub 2005 Mar 2 - added putative function |
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| Transport families are assigned according to Transport
Classification Database (http://www.tcdb.org/tcdb/). Click on TC number to
get into the DB. |
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| PfID |
Putative function |
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Transcript |
Cellular localization |
| a-Type channels (TC 1.A) |
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| VOLTAGE-GATED
ION CHANNEL SUPERFAMILY (TC 1.A.1) |
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K+ channel |
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| PF14_0342 |
Ion channel, putative |
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K+ channel |
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| MIXED
FUNCTION GLYCEROL FACILITATOR/AQUAPORIN, GlpF (TC 1.A.8.2.2) |
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| PF11_0338 |
Aquaglyceroporin |
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| THE
SMALL CONDUCTANCE MECHANOSENITIVE ION CHANNEL (MSCS) FAMILY (TC 1.A.23) |
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| PF11_0092 |
Mechanosensitive ion channel |
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| CorA
METAL ION TRANSPORTER FAMILY (TC 1.A.35) |
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| PF14_0255 |
CorA-like Mg2+ transporter protein,
putative |
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| PF11_0210 |
Metal ion channel - Mg2+, Co2+ and Ni2+ |
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| MAL13P1.23 |
CorA-like Mg2+ transporter protein,
putative |
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| COPPER
TRANSPORTER (Ctr) FAMILY (TC
1.A.56) |
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| PF14_0211 |
Copper channel |
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| PF14_0369 |
Copper channel |
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Apicoplast |
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| Ion
Channel-Adenylate Cyclase Family (activity of ion channel domain not confirmed; family yet
to be included in the TC system) |
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| PF14_0043 |
Protein with ion channel and adenylate cyclase
domains |
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| b-Type channels (TC 1.B) |
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| VOLTAGE-DEPENDENT
ANION CHANNEL (VDAC) PORIN (TC
1.B.8.1.1) |
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| PF14_0301 |
Mitochondrial/apicoplast outer membrane
porin |
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Mitochondrion/Apicoplast |
| Electrochemical
Potential-driven Transporters (TC 2.A) |
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| MAJOR
FACILITATOR SUPERFAMILY (TC 2.A.1) |
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| PFL0170w |
Transporter |
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| SUGAR
PORTER FAMILY (TC 2.A.1.1) |
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Hexose transporter 1 (PfHT1) |
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| PFI0955w |
Sugar transporter, putative |
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| PFI0785 |
Sugar transporter |
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| DRUG:H+
ANTIPORTER-1 FAMILY (TC 2.A.1.2) |
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| PFB0275w |
Metabolite/drug transporter |
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| PF11_0059 |
Metabolite/drug transporter |
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| PF14_0260 |
Metabolite/drug transporter |
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| PF14_0387 |
Metabolite/drug transporter |
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| PFE0825w |
Transporter, putative; Metabolite/drug transporter |
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| MONOCARBOXYLATE
PORTER FAMILY (TC 2.A.1.13)/ OXALATE:FORMATE ANTIPORTER FAMILY (TC 2.A.1.11) |
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| PFB0465c |
Monocarboxylate transporter |
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| PFI1295c |
Monocarboxylate transporter |
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| PEPTIDE-ACETYLCOENZYME
A TRANSPORTER FAMILY (TC 2.A.1.25) |
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| PF10_0360 |
Acetyl-CoA transporter |
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ER/Golgi |
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| GLYCOSIDE-PENTOSIDE-HEXURONIDE:CATION
SYMPORTER FAMILY (TC 2.A.2) |
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| PFE1455w |
Sugar transporter, putative; Sugar:cation symporter |
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| ORGANO
ANION TRANSPORTER FAMILY (TC 2.A.60) |
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| PFF0690c |
Organic anion transporter |
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| FOLATE-BIOPTERIN
TRANSPORTER FAMILY (TC 2.A.71) |
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| MAL8P1.13 |
Integral membrane protein; Folate/biopterin transporter |
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| PF11_0172 |
Folate/biopterin transporter |
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| PF10_0215 |
Hypothetical protein; Metabolite/vitamin transporter |
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| NOVEL
PUTATIVE TRANSPORTER FAMILY |
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| PFA0240w |
Transporter, putative |
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| PFA0245w |
Transporter, putative |
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| PFC0530w |
Transporter, putative |
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| PFI0720w |
Transporter, putative |
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| PF11_0310 |
Transporter, putative |
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| CATION
DIFFUSION FACILITATOR (CDF) FAMILY (TC 2.A.4) |
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| PF07_0065 |
Zinc transporter, putative |
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| ZINC
(Zn2+)-IRON
(Fe2+) PERMEASE FAMILY (TC 2.A.5) |
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| PFF0450c |
Zn2+ or Fe2+ permease |
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| Resistance-Nodulation-Cell
Division Superfamily (TC 2.A.6) |
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| EUKARYOTIC
(PUTATIVE) STEROL TRRANSPORTER FAMILY (TC 2.A.6.6) |
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| PFA0375c |
Lipid/sterol:H+ symporter |
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Food vacuole |
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| DRUG/METABOLIET
TRANSPORTER SUPERFAMILY (TC 2.A.7) |
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| PF07_0070 |
Drug/metabolite transporter |
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| PFE0785c |
Drug/metabolite transporter; GDP-fucose transporter ? |
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| 10
TMS DRUG/METABOLITE EXPORTER FAMILY (TC 2.A.7.3) |
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| PF07_0064 |
Drug/metabolite exporter,
drug/metabolite transporter |
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Chloroquine resistance transporter,
PfCRT |
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Food vacuole |
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| TRIOSE-PHOSPHATE
TRANSPORTER FAMILY (TC 2.A.7.9) |
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Triose- or hexose-Pi: Pi antiporter |
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Apicoplast |
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Phosphoenolpyruvate: Pi antiporter |
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Apicoplast |
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| PFL0890c |
Triose- or hexose-Pi:Pi antiporter |
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| GDP-MANNOSE:
GMP ANTIPORTER FAMILY (TC 2.A.7.13) |
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| PFB0535w |
GDP-fucose:GMP antiporter, putative |
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ER/Golgi |
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| UDP-N-ACETYL
GLUCOSAMINE: UMP ANTIPORTER FAMILY (TC 2.A.7.10) |
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| PFE0260w |
UDP-N-acetyl glucosamine:UMP
antiporter |
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ER/Golgi |
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| UDP-GALACTOSE:
UMP ANTIPORTER FAMILY (TC 2.A.7.11) |
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| PF11_0141 |
UDP-galactose transporter, putative;
UDP-galactose:UMP antiporter |
ER/Golgi |
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| AMINO
ACID/AUXIN PERMEASE FAMILY (TC 2.A.18) |
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| PFF1430c |
Amino acid transporter |
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| PFL0420w |
Amino acid transporter |
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| PFL1515c |
Amino acid transporter |
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| Ca2+:CATION
ANTIPORTER FAMILY (TC 2.A.19) |
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| PFF0170w |
Ca2+:H+ antiporter |
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Mitochondrion |
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| INORGANIC
PHOSPHATE TRANSPORTER FAMILY (TC 2.A.20) |
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| MAL13P1.206 |
Na+ -dependent Pi
transporter, sodium-dependent phosphate transporter |
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| NEUROTRANSMITTER:Na+ SYMPORTER
FAMILY (TC 2.A.22) |
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| PFB0435c |
Amino acid transporter, putative |
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| PFE0775c |
Amino acid transporter |
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| PF11_0334 |
Amino acid transporter, putative |
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| MITOCHONDRIAL
CARRIER (MC) FAMILY (TC 2.A.29) |
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| PF10_0051 |
ADP/ATP antiporter |
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Mitochondrion |
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ADP/ATP antiporter |
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Mitochondrion |
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| PFI0425w |
Transporter |
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Mitochondrion |
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| PFL2000w |
Transporter |
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Mitochondrion |
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| PF13_0359 |
Transporter |
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Mitochondrion |
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| PFI0255c |
Mitochondrial carrier protein,
putative |
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Mitochondrion |
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| PFD0370w |
Hypothetical protein; mitochondrial carrier protein, putative |
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Mitochondrion |
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| PFD0367w |
Mitochondrial carrier protein,
putative |
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Mitochondrion |
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| PF08_0031 |
Dicarboxylate/tricarboxylate
antiporter |
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Mitochondrion |
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| PFL0110c |
Pi : H+ symporter |
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Mitochondrion |
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| PF08_0093 |
Transporter |
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Mitochondrion |
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| PFA0435w |
Hypothetical protein; mitochondrial carrier family |
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Mitochondrion |
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| PFL1145w |
Transporter |
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Mitochondrion |
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| PFA0415c |
Hypothetical protein; mitochondrial carrier family |
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Mitochondrion |
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| MONOVALENT
CATION:H+ ANTIPORTER-1
FAMILY (TC 2.A.36) |
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| PF13_0019 |
Na+:H+ exchanger |
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| FORMATE-NITRITE
TRANSPORTER FAMILY (TC 2.A.44) |
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| PFC0725c |
Formate-nitrite transporter |
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| SULPHATE
PERMEASE FAMILY (TC 2.A.53) |
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| PF14_0679 |
Inorganic anion exchanger, inorganic
anion antiporter |
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| METAL
ION (Mn2+-IRON) TRANSPORTER FAMILY (TC 2.A.55) |
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| PFE1185w |
Divalent cation (metal) :H+ symporter |
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Food vacuole |
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| EQUILIBRATIVE
NUCLEOSIDE TRANSPORTER FAMILY (TC 2.A.57) |
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| PFA0160c |
Nucleoside transporter |
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| MAL8P1.32 |
Nucleoside transporter |
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Nucleoside transporter PfENT1 |
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| PF14_0662 |
Nucleoside transporter |
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| MULTI
ANTIMICROBIAL EXTRUSION (MATE) FAMILY (TC 2.A.66.1) |
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| PFB0580w |
Organic solutes/Na+ or H+ antiporter |
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| THE
VACUOLAR IRON TRANSPORTER (VIT) FAMILY (TC 2.A.89 ) |
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| PFL1140w |
Fe2+ transporter |
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Food vacuole |
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| Primary
Active (P-P-bond-hydrolysis-driven) Transporters
(TC 3.A) |
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| ATP-BINDING
CASSETTE (ABC) SUPERFAMILY (TC 3.A.1) |
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| PFC0875w |
ABC transporter |
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| PF08_0098 |
ABC1 family, putative |
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Mitochondrion |
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| PF08_0078 |
Hypothetical protein; ABC transporter, putative |
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Apicoplast |
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| MHC
PEPTIDE TRANSPORTER (TAP) FAMILY (TC 3.A.1.209) |
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