| Genes coding for transport proteins |
|
|
| Source: Martin RE, Henry RI, Abbey JL, Clements JD, Kirk K. The 'permeome' of the malaria parasite: an
overview of the membrane transport proteins of Plasmodium falciparum. Genome
Biol. 2005;6(3):R26. Epub 2005 Mar 2 - added putative function |
| Transport families are assigned according to Transport
Classification Database (http://www.tcdb.org/tcdb/). Click on TC number to
get into the DB. |
| TC/PfID |
Putative
function |
|
Transcript |
Cellular localization |
EC |
|
| TC 1.A |
a-Type channels |
|
|
|
|
|
|
| TC 1.A.1 |
VOLTAGE-GATED ION CHANNEL
SUPERFAMILY |
|
|
K+ channel |
|
| PF14_0342 |
Ion channel,
putative |
|
|
|
|
K+ channel |
|
| TC 1.A.8.2.2 |
MIXED FUNCTION
GLYCEROL FACILITATOR/AQUAPORIN, GlpF |
|
| PF11_0338 |
Aquaglyceroporin |
|
| TC 1.A.23 |
SMALL
CONDUCTANCE MECHANOSENITIVE ION CHANNEL (MSCS) FAMILY |
|
| PF11_0092 |
Mechanosensitive
ion channel |
|
| TC 1.A.35 |
CorA METAL ION TRANSPORTER
FAMILY |
|
|
|
| PF14_0255 |
CorA-like Mg2+
transporter protein, putative |
|
| PF11_0210 |
Metal ion
channel - Mg2+, Co2+ and Ni2+ |
|
| MAL13P1.23 |
CorA-like Mg2+
transporter protein, putative |
|
| TC 1.A.56 |
COPPER TRANSPORTER (Ctr)
FAMILY |
|
| PF14_0211 |
Copper channel |
|
| PF14_0369 |
Copper channel |
|
Apicoplast |
|
|
Ion
Channel-Adenylate Cyclase Family (activity of ion channel domain not
confirmed; family yet to be included
in the TC system) |
| PF14_0043 |
Protein with ion channel and adenylate cyclase
domains |
|
|
|
4.6.1.1 |
|
| TC 1.B |
b-Type channels |
|
| TC 1.B.8.1.1 |
VOLTAGE-DEPENDENT ANION
CHANNEL (VDAC) PORIN |
|
| PF14_0301 |
Mitochondrial/apicoplast outer membrane
porin |
|
|
Mitochondrion/Apicoplast |
|
| TC 2.A |
Electrochemical
Potential-driven Transporters |
|
|
| TC
2.A.1 |
MAJOR FACILITATOR SUPERFAMILY |
|
| PFL0170w |
Transporter |
|
|
|
| TC 2.A.1.1 |
SUGAR PORTER FAMILY |
|
|
Hexose
transporter 1 (PfHT1) |
|
| PFI0955w |
Sugar
transporter, putative |
|
| PFI0785c |
Sugar
transporter |
|
| TC 2.A.1.2 |
DRUG:H+ ANTIPORTER-1 FAMILY |
|
| PFB0275w |
Metabolite/drug
transporter |
|
| PF11_0059 |
Metabolite/drug
transporter |
|
| PF14_0260 |
Metabolite/drug
transporter |
|
| PF14_0387 |
Metabolite/drug
transporter |
|
| PFE0825w |
Transporter, putative; Metabolite/drug
transporter |
|
| TC 2.A.1.13 |
MONOCARBOXYLATE
PORTER FAMILY/ OXALATE:FORMATE ANTIPORTER FAMILY |
| TC 2.A.1.11 |
| PFB0465c |
Monocarboxylate
transporter |
|
|
|
| PFI1295c |
Monocarboxylate
transporter |
|
| TC 2.A.1.25 |
PEPTIDE-ACETYL
COENZYME A TRANSPORTER FAMILY |
|
| PF10_0360 |
Acetyl-CoA
transporter |
|
|
ER/Golgi |
|
|
|
| TC 2.A.2 |
GLYCOSIDE-PENTOSIDE-HEXURONIDE:CATION
SYMPORTER FAMILY |
|
| PFE1455w |
Sugar transporter, putative; Sugar:cation symporter |
|
|
|
| TC 2.A.60 |
ORGANO ANION TRANSPORTER FAMILY |
|
| PFF0690c |
Organic anion
transporter |
|
|
|
| TC 2.A.71 |
FOLATE-BIOPTERIN TRANSPORTER
FAMILY |
|
| MAL8P1.13 |
Integral membrane protein; Folate/biopterin transporter |
|
| PF11_0172 |
Folate/biopterin
transporter |
|
| PF10_0215 |
Hypothetical protein; Metabolite/vitamin
transporter |
|
|
NOVEL PUTATIVE
TRANSPORTER FAMILY |
|
| PFA0240w |
Transporter,
putative |
|
|
|
| PFA0245w |
Transporter,
putative |
|
| PFC0530w |
Transporter,
putative |
|
| PFI0720w |
Transporter,
putative |
|
| PF11_0310 |
Transporter,
putative |
|
| TC
2.A.4 |
CATION DIFFUSION
FACILITATOR (CDF) FAMILY |
|
| PF07_0065 |
Zinc
transporter, putative |
|
|
|
| TC
2.A.5 |
ZINC (Zn2+)-IRON (Fe2+) PERMEASE FAMILY |
|
| PFF0450c |
Zn2+ or Fe2+ permease |
|
| TC 2.A.6 |
Resistance-Nodulation-Cell
Division Superfamily |
|
|
| TC 2.A.6.6 |
EUKARYOTIC
(PUTATIVE) STEROL TRRANSPORTER FAMILY |
|
| PFA0375c |
Lipid/sterol:H+ symporter |
|
|
Food vacuole |
|
| TC 2.A.7 |
DRUG/METABOLIET TRANSPORTER
SUPERFAMILY |
|
| PF07_0070 |
Drug/metabolite
transporter |
|
3.6.3.44 |
|
| PFE0785c |
Drug/metabolite
transporter; GDP-fucose transporter ? |
|
3.6.3.44 |
|
| TC 2.A.7.3 |
10 TMS DRUG/METABOLITE
EXPORTER FAMILY |
|
|
|
| PF07_0064 |
Drug/metabolite
exporter, drug/metabolite transporter |
|
|
|
3.6.3.44 |
|
|
Chloroquine
resistance transporter, PfCRT |
|
Food vacuole |
|
| TC 2.A.7.9 |
TRIOSE-PHOSPHATE TRANSPORTER
FAMILY |
|
|
|
|
Triose- or
hexose-Pi: Pi antiporter |
|
Apicoplast |
|
|
Phosphoenolpyruvate:
Pi antiporter |
|
Apicoplast |
|
| PFL0890c |
Triose- or
hexose-Pi:Pi antiporter |
|
| TC 2.A.7.13 |
GDP-MANNOSE:
GMP ANTIPORTER FAMILY |
|
| PFB0535w |
GDP-fucose:GMP
antiporter, putative |
|
|
ER/Golgi |
|
|
|
| TC 2.A.7.10 |
UDP-N-ACETYL
GLUCOSAMINE: UMP ANTIPORTER FAMILY |
|
| PFE0260w |
UDP-N-acetyl
glucosamine:UMP antiporter |
|
|
ER/Golgi |
|
|
|
| TC 2.A.7.11 |
UDP-GALACTOSE: UMP ANTIPORTER
FAMILY |
|
| PF11_0141 |
UDP-galactose
transporter, putative; UDP-galactose:UMP antiporter |
|
ER/Golgi |
|
|
|
| TC 2.A.18 |
AMINO ACID/AUXIN PERMEASE
FAMILY |
|
|
|
| PFF1430c |
Amino acid
transporter |
|
| PFL0420w |
Amino acid
transporter |
|
| PFL1515c |
Amino acid
transporter |
|
| TC 2.A.19 |
Ca2+:CATION ANTIPORTER FAMILY
(TC 2.A.19) |
|
| PFF0170w |
Ca2+:H+ antiporter |
|
|
Mitochondrion |
|
| TC 2.A.20 |
INORGANIC PHOSPHATE
TRANSPORTER FAMILY |
|
| MAL13P1.206 |
Na+ -dependent Pi transporter,
sodium-dependent phosphate transporter |
|
| TC 2.A.22 |
NEUROTRANSMITTER:Na+ SYMPORTER FAMILY |
|
|
|
| PFB0435c |
Amino acid
transporter, putative |
|
| PFE0775c |
Amino acid
transporter |
|
| PF11_0334 |
Amino acid
transporter, putative |
|
| TC 2.A.29 |
MITOCHONDRIAL CARRIER (MC)
FAMILY |
|
| PF10_0051 |
ADP/ATP
antiporter |
|
|
Mitochondrion |
|
|
ADP/ATP
antiporter |
|
Mitochondrion |
|
| PFI0425w |
Transporter |
|
Mitochondrion |
|
| PFL2000w |
Transporter |
|
Mitochondrion |
|
| PF13_0359 |
Transporter |
|
Mitochondrion |
|
| PFI0255c |
Mitochondrial
carrier protein, putative |
|
Mitochondrion |
|
| PFD0367w |
Mitochondrial
carrier protein, putative |
|
Mitochondrion |
|
| PF08_0031 |
Dicarboxylate/tricarboxylate
antiporter |
|
|
Mitochondrion |
|
| PFL0110c |
Pi : H+ symporter |
|
Mitochondrion |
|
| PF08_0093 |
Mitochondrial
carrier protein, putative |
|
Mitochondrion |
|
| PFA0435w |
Hypothetical
protein; mitochondrial carrier family |
|
|
Mitochondrion |
|
| PFL1145w |
Transporter |
|
Mitochondrion |
|
| PFA0415c |
Mitochondrial
carrier protein, putative |
|
Mitochondrion |
|
| TC 2.A.36 |
MONOVALENT
CATION:H+ ANTIPORTER-1
FAMILY |
|
| PF13_0019 |
Na+:H+ exchanger |
|
|
|
| TC 2.A.44 |
FORMATE-NITRITE TRANSPORTER
FAMILY |
|
| PFC0725c |
Formate-nitrite
transporter |
|
| TC 2.A.53 |
SULPHATE PERMEASE FAMILY |
|
|
|
|
Inorganic anion exchanger, inorganic
anion antiporter |
|
| TC 2.A.55 |
METAL ION (Mn2+-IRON)
TRANSPORTER FAMILY |
|
| PFE1185w |
Divalent
cation (metal) :H+ symporter |
|
|
Food vacuole |
|
| TC 2.A.57 |
EQUILIBRATIVE NUCLEOSIDE
TRANSPORTER FAMILY |
|
| PFA0160c |
Nucleoside
transporter |
|
|
|
|
Nucleoside
transporter PfNT2 |
|
|
Nucleoside
transporter PfENT1 |
|
| PF14_0662 |
Nucleoside
transporter |
|
| TC 2.A.66.1 |
MULTI ANTIMICROBIAL
EXTRUSION (MATE) FAMILY |
|
| PFB0580w |
Organic
solutes/Na+ or H+ antiporter |
|
|
|
| TC 2.A.89 |
THE VACUOLAR IRON
TRANSPORTER (VIT) FAMILY |
|
| PFL1140w |
Fe2+ transporter |
|
Food vacuole |
|
| TC 3.A |
Primary
Active P-P-bond-hydrolysis-driven Transporters |
|
| TC
3.A.1 |
ATP-BINDING CASSETTE (ABC)
SUPERFAMILY |
|
| PFC0875w |
ABC
transporter |
|
| PF08_0098 |
ABC1 family,
putative |
|
Mitochondrion |
|
| PF08_0078 |
Hypothetical protein; ABC
transporter, putative |
|
Apicoplast |
|
| TC 3.A.1.209 |
MHC PEPTIDE TRANSPORTER (TAP)
FAMILY |
|
| PFC0125w |
ABC
transporter (TAP family) |
|
|
Apicoplast |
|
| PF11_0466 |
ABC
transporter (TAP family) |
|
Apicoplast/Mitochondrion |
|
| PFL0495c |
ABC
transporter (TAP family) |
|
Mitochondrion/ER/Golgi |
|
| TC 3.A.1.201 |
MULTIDRUG RESISTANCE
EXPORTER (MDR) FAMILY |
|
|
|
|
Multidrug resistance protein (MDR family)
PfMDR1 |
|
Food vacuole |
3.6.3.44 |
|
| PF13_0218 |
ABC
transporter (MDR family) |
|
Food vacuole |
3.6.3.44 |
|
| TC 3.A.1.210 |
HEAVY METAL TRANSPORTER (HMT) FAMILY |
| DPL |
| PF13_0271 |
ABC
transporter (HMT family) |
|
|
Apicoplast |
|
|
Multidrug resistance protein 2 (HMT
family) PfMDR2 |
|
3.6.3.44 |
|
| TC 3.A.1.208 |
CONJUGATE TRANSPORTER (CT)
FAMILY |
|
|
ABC
transporter (CT family) PfMRP |
|
|
ABC
transporter (CT family) |
|
| TC 3.A.1.204 |
EYE PIGMENT PRECURSOR
TRANSPORTER (EPP) FAMILY |
| EPD |
| PF14_0244 |
ABC transporter; EPP family |
|
|